Abstract #3691

Metabolic Interactions of Simultaneous 18F-FDG PET and Hyperpolarized 13C MRI

Mette H. Lauritzen¹, Milton Merchant², Taichang Jang², Keshav Datta¹, Ralph E. Hurd¹, Shie-Chau Liu¹, Jae Mo Park¹, Lawrence Recht², and Daniel M. Spielman¹

¹Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States, ²Department of Neurology, Stanford University School of Medicine, Stanford, CA, United States

Simultaneous hyperpolarized ¹³C-pyruvate MRI and ¹⁸F-FDG PET imaging have the several potential applications, especially for understanding the complex metabolic processes of cancer. However, we hypothesized the relatively high concentrations of ¹³C-pyruvate used in hyperpolarized MRI could interfere with the ¹⁸F-FDG uptake when administrated simultaneously, because their metabolic products compete for the same pathways. In this study, we examined the effect of injected pyruvate and lactate on ¹⁸F-FDG uptake in healthy rats and in rats with implanted C6 gliomas, and discuss the metabolic interactions observed.

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