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Abstract #3691

Metabolic Interactions of Simultaneous 18F-FDG PET and Hyperpolarized 13C MRI

Mette H. Lauritzen1, Milton Merchant2, Taichang Jang2, Keshav Datta1, Ralph E. Hurd1, Shie-Chau Liu1, Jae Mo Park1, Lawrence Recht2, and Daniel M. Spielman1

1Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States, 2Department of Neurology, Stanford University School of Medicine, Stanford, CA, United States

Simultaneous hyperpolarized 13C-pyruvate MRI and 18F-FDG PET imaging have the several potential applications, especially for understanding the complex metabolic processes of cancer. However, we hypothesized the relatively high concentrations of 13C-pyruvate used in hyperpolarized MRI could interfere with the 18F-FDG uptake when administrated simultaneously, because their metabolic products compete for the same pathways. In this study, we examined the effect of injected pyruvate and lactate on 18F-FDG uptake in healthy rats and in rats with implanted C6 gliomas, and discuss the metabolic interactions observed.

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