Epidemiological evidence strongly suggests that chronic low-dose aspirin usage leads to a significantly lower incidence of cancer and metastatic disease. Given its emergent role as a chemopreventive, it is highly desirable to develop a method to monitor aspirin pharmacokinetics and metabolism in real time and in vivo. We have recently synthesized and hyperpolarized single and double 13C-labeled aspirin, monitored chemical acetylation in hyperpolarized phantom experiments, and determined metabolism and biodistribution of hyperpolarized 13C aspirin in mice.
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