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Abstract #3711

Hyperpolarized In vivo pH Imaging Reveals Grade-Dependent Interstitial Acidification

David E Korenchan1, Robert Bok1, Renuka Sriram1, Romelyn Delos Santos1, Hecong Qin1,2, Daniel B Vigneron1,2, David M Wilson1, John Kurhanewicz1,2, and Robert R Flavell1

1Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, United States, 2Bioengineering, UC San Francisco, San Francisco, CA, United States

Changes in cellular metabolism, perfusion, and proton export that occur during indolent-to-aggressive transition in prostate cancer (PCa) likely lead to a lower extracellular pH (pHe) in vivo, promoting an aggressive, treatment-resistant phenotype. To measure this interstitial acidification, we implemented a hyperpolarized (HP) imaging protocol that measured lactate-to-pyruvate ratio, perfusion, and pHe in a murine model of prostate cancer, the TRAMP mouse. Our results indicated higher pyruvate-to-lactate conversion, lower perfusion, and lower pHe in high-grade tumors, suggesting a correlation between the three parameters and implicating low pHe in the development of aggressive PCa.

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