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Abstract #3720

Hyperpolarized [1-13C]pyruvate MRS reveals early-phase transition of energy metabolism in multicellular spheroid tumors

Yoichi Takakusagi1,2, Kaori Takakusagi1, Kaori Inoue2, and Kazuhiro Ichikawa2,3

1National Institute of Radiological Sciences, QST, Chiba, Japan, 2Incubation Center for Advanced Medical Science, Kyushu University, Fukuoka, Japan, 3Department of Pharmacy, Nagasaki International Unversity, Sasebo, Japan

Hyperpolarized [1-13C]pyruvate MRS was conducted to directly monitor the transition of energy metabolism in tiny multicellular tumor spheroids as a model of early tumorigenesis. As compared with normal tumor cells, the lactate formation from pyruvate was significantly amplified in the tumor spheroids, even in a few hundred micrometer i.d. of smaller ones with no blood vessel formation. These results imply that formation of the sterical structure itself causes the transition of energy metabolism from mitochondria to cytoplasm in tumor tissues. HP [1-13C]pyruvate MRS may thus allow detection of early tumorigenesis by targeting the increased aerobic glycolysis in the initial stage, if much higher performance of HP measurement is realized.

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