Abstract #3723

Quantitative MRI comparison of neurological and hepatic forms of Wilson disease

Monika Dezortova¹, Vit Herynek¹, Petr Dusek², Julio Acosta-Cabronero³, Radan Bruha⁴, Filip Jiru¹, and Milan Hajek¹

¹MR-Unit, Dept. Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Dept Neurology and Center of clinical Neuroscience, Charles University, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic, ³Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, ⁴4th Dept. Internal Medicine, Charles University, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic

We examined 40 patients with neurological and hepatic form of Wilson disease by susceptibility mapping at 3T and T1 and T2 relaxometry at 1.5T and 3T. We were able to distinguish patients with neurological form from hepatic form and healthy controls based on quantitative relaxometry and susceptibility mapping. Higher susceptibility observed in the globus pallidus, putamen, and caudate nucleus in patients with neurological form corresponds to higher iron content while higher susceptibility in the thalamus corresponds rather to demyelination.

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