The aim of our study was to assess changes in cortical thickness, cortical area and cortical volume of gray matter (GM) for hypothyroid patients. We had acquired high-resolution 3D T1 weighted structural data for both control (24) and hypothyroid subjects (22). Reduced gray matter cortical thickness was observed in lateraloccipital cortex, postcentral gyrus, medialorbitofrontal cortex, lingual gyrus, superior and inferior parietal cortex in hypothyroid patients as compare to controls. These findings of reduced gray matter (CTh) suggest abated activities of motor, attention, working memory and executive cognitive function in hypothyroid patients.
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