Abstract #3729

Radiological Imaging of Brain Iron Deposits and T1 quantification feasibility using 3D UTE Cones.

Piotr Wielopolski¹, Elene vroegindeweij², Agnita Boon³, Janneke Langendonk², and Juan Antonio Hernandez-Tamames¹

¹Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, ²Porphyria Center Rotterdam, Center for lysosomal and metabolic disease, Erasmus MC, Rotterdam, Netherlands, ³Neurology, Erasmus MC, Rotterdam, Netherlands

In this work, we demonstrate that 3D UTE cones enables the possibility of T1 contrast and T1 relaxometry of iron deposits in the brain. We present radiological images of brain iron and T1 quantification of iron deposits in a pathology with an exacerbated amount of iron in the brain. We demonstrate that even for conventional T2 and T2* mapping is challenging to obtain relaxometry. However, it is feasible for a 3D UTE cones sequence.

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