Surgical resection of the seizure focus in the mesial temporal lobe is a common treatment of drug-resistant temporal lobe epilepsy (TLE) with an approximately 80% success rate. Our previous work showed that presurgical MRI-based functional and structural network connectivity can identify those TLE patients with the most unfavorable seizure outcomes. The goal of this work was to increase specificity of our prediction by characterizing those with seizure free and favorable outcomes. The results suggest that when impairment in functional connectivity of the seizure propagation network extends to the contralateral hemisphere, patients will experience rare post-surgical seizures sooner.
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