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Abstract #3735

The association between brain volumes and physical frailty in older individuals

Ilse Kant1,2, Jeroen de Bresser1,3, Simone van Montfort2, Ellen Aarts1,2, Ilona Bader2, Yarit Wiggerts2, Georg Winterer4, Claudia Spies4, Arjen Slooter2, and Jeroen Hendrikse1

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Intensive Care, UMC Utrecht, Utrecht, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Anesthesiology and Intensive Care, Charité Universitätsmedizin, Berlin, Germany

Physical frailty develops with increasing age and is a chronic state of vulnerability that is associated with disability and cognitive decline. Few studies have assessed the underlying structural brain abnormalities of physical frailty. We therefore examined the association between brain volumes on MRI and physical frailty in a group of 214 non-demented elderly participants. Frail participants showed a lower total brain volume and a lower grey matter volume compared to pre-frail and non-frail participants. Furthermore, pre-frail participants showed more cortical infarcts compared to non-frail participants. These brain abnormalities could be the underlying substrate of the physical frailty phenotype.

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