Abstract #3735

The association between brain volumes and physical frailty in older individuals

Ilse Kant^1,2, Jeroen de Bresser^1,3, Simone van Montfort², Ellen Aarts^1,2, Ilona Bader², Yarit Wiggerts², Georg Winterer⁴, Claudia Spies⁴, Arjen Slooter², and Jeroen Hendrikse¹

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Intensive Care, UMC Utrecht, Utrecht, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Anesthesiology and Intensive Care, Charité Universitätsmedizin, Berlin, Germany

Physical frailty develops with increasing age and is a chronic state of vulnerability that is associated with disability and cognitive decline. Few studies have assessed the underlying structural brain abnormalities of physical frailty. We therefore examined the association between brain volumes on MRI and physical frailty in a group of 214 non-demented elderly participants. Frail participants showed a lower total brain volume and a lower grey matter volume compared to pre-frail and non-frail participants. Furthermore, pre-frail participants showed more cortical infarcts compared to non-frail participants. These brain abnormalities could be the underlying substrate of the physical frailty phenotype.

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