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Abstract #3740

Quantitative Susceptibility Mapping of post-mortem ALS brains at 7T

Chaoyue Wang1, Benjamin Tendler1, Menuka Pallebage-Gamarallage2, Olaf Ansorge2, Ricarda AL Menke1, Martin R Turner2, Sean Foxley3, and Karla L Miller1

1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Department of Radiology, University of Chicago, Chicago, IL, United States

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor system and its wider cortical connections. Progress in therapeutic development in ALS is compromised by a lack of specific biomarkers. In this work, we describe a platform for acquiring QSM data in post-mortem brains and propose a protocol for post-mortem QSM reconstruction. Preliminary results have shown that ALS brains had substantially greater mean susceptibility in motor cortex than control brains, which indicates that QSM has the potential to accurately quantify iron concentration and thus serve as an imaging biomarker for ALS.

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