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Abstract #3760

Evaluate the Methanol-induced Alzheimer’s Disease Monkey Model by Resting-state Functional MRI

Yin-Chieh Liu1, Chaoyang Tian2, Ssu-Ju Li1, Xudong Zhao3, Ting-Chun Lin1, Jianjun Li4, Ching-Wen Chang1, Kaimin Wang2, Yingshan Yang2, Yu-Chun Lo5, YuanYe Ma2, You-Yin Chen*1, Feng Chen*4, and Hsin-Yi Lai*6

1Department of Biomedical Engineering, National Yang Ming University, Taipei City, Taiwan, 2Department of Research and Development, Hainan Jingang Biotech Co.,Ltd, Haikou, China, 3Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 4Department of Radiology, Hainan General Hospital, Haikou, Haikou, China, 5The PhD Program for Neural Regenerative Medicine, Taipei Medical University, Taipei City, Taiwan, 6Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou City, China

Alzheimer’s disease (AD) is the most comment neurodegenerative disorder that results in the irreversible loss of neurons, especially in the cortex and hippocampus. The aim of this study is to evaluate the changes of brain functional connectivity in methanol-induced AD monkey. To find the corresponding response areas of AD, five brain regions defined by independent component analysis (ICA) were analyzed using seed-based correlation analysis (SCA). Results of resting-sate fMRI showed that the AD Monkey presented abnormal functional connectivity in anterior cingulate cortex (ACC), primary visual cortex (V1) and ventrolateral prefrontal cortex (VLPFC), those were also shown in AD patient.

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