Abstract #3762

Bilateral salpingo-oophorectomy prior to natural menopause is associated with Alzheimer’s disease-like reductions in gray and white matter

Suzanne T Witt¹, Åsa Rydmark Kersley², Elisabet Classon³, Nina Lykke⁴, Magrit Shildrick⁴, Cecilia Åsberg⁴, Cheryl Grady⁵, Elvar Theordorsson⁶, Jan Ernerudh⁶, Elisabeth Åvall Lundqvist⁶, Preben Kjølhede^2,6, and Gillian Einstein^5,6

¹CMIV, Linköping University, Linköping, Sweden, ²Womens' Clinic, University Hospital Linköping, Linköping, Sweden, ³Dept. of Acute Internal Medicine and Geriatrics, Linköping University, Linköping, Sweden, ⁴Unit of Gender Studies, Linköping University, Linköping, Sweden, ⁵University of Toronto, Toronto, ON, Canada, ⁶Dept. of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

Women with Breast Cancer Gene mutations (BRCAm) are recommended to undergo prophylactic bilateral salpingo-oophorectomy prior to natural menopause (PNM-BSO) in order to reduce the risk of ovarian cancer. This surgery is associated with an increased risk of developing Alzheimer's disease (AD). In comparison with healthy women, BRCAm women who had undergone PNM-BSO exhibited decreased gray matter volume across frontal and medial-temporal regions, as measured using the quantitative QRAPMASTER sequence. These regions included many previously linked with AD including, parahippocampal gyrus, cingulate cortex, and inferior temporal gyrus. White matter reductions were only observed in a limited number of superior longitudinal tracts.

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