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Abstract #3762

Bilateral salpingo-oophorectomy prior to natural menopause is associated with Alzheimer’s disease-like reductions in gray and white matter

Suzanne T Witt1, Åsa Rydmark Kersley2, Elisabet Classon3, Nina Lykke4, Magrit Shildrick4, Cecilia Åsberg4, Cheryl Grady5, Elvar Theordorsson6, Jan Ernerudh6, Elisabeth Åvall Lundqvist6, Preben Kjølhede2,6, and Gillian Einstein5,6

1CMIV, Linköping University, Linköping, Sweden, 2Womens' Clinic, University Hospital Linköping, Linköping, Sweden, 3Dept. of Acute Internal Medicine and Geriatrics, Linköping University, Linköping, Sweden, 4Unit of Gender Studies, Linköping University, Linköping, Sweden, 5University of Toronto, Toronto, ON, Canada, 6Dept. of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

Women with Breast Cancer Gene mutations (BRCAm) are recommended to undergo prophylactic bilateral salpingo-oophorectomy prior to natural menopause (PNM-BSO) in order to reduce the risk of ovarian cancer. This surgery is associated with an increased risk of developing Alzheimer's disease (AD). In comparison with healthy women, BRCAm women who had undergone PNM-BSO exhibited decreased gray matter volume across frontal and medial-temporal regions, as measured using the quantitative QRAPMASTER sequence. These regions included many previously linked with AD including, parahippocampal gyrus, cingulate cortex, and inferior temporal gyrus. White matter reductions were only observed in a limited number of superior longitudinal tracts.

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