Abstract #3772

Cortical Cerebral Blood Flow in Aging: Effects of Haematocrit, Sex and Ethnicity.

Lorna A. Smith¹, Andrew Melbourne², David Owen², M. Jorge Cardoso², Carole H. Sudre², Therese Tillin¹, Magdalena Sokolska³, David Atkinson⁴, Nish Chaturvedi¹, Sebastien Ourselin², Alun D. Hughes¹, Frederik Barkhof^5,6,7, and H. R. Jager⁸

¹Dept. of Population Science and Experimental Medicine, Institute of Cardiovascular Sciences, University College London, London, United Kingdom, ²Translational Imaging Group, Dept. of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Dept. of Medical Physics and Biomedical Engineering, University College Hospital, London, United Kingdom, ⁴Centre for Medical Imaging, University College London, London, United Kingdom, ⁵Inst. of Neurology, University College London, London, United Kingdom, ⁶Inst. of Healthcare Engineering, University College London, London, United Kingdom, ⁷Dept. of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, Netherlands, ⁸Neuroradiological Academic Unit, Dept. of Brain Repair and Rehabilitation, University College London, London, United Kingdom

Cerebral blood flow (CBF) estimates using arterial spin labelling (ASL) show unexplained variability in older populations. We studied the impact of haematocrit (Hct) on CBF quantification in a tri-ethnic elderly population cohort. Hct was measured from blood samples and pseudo-continuous ASL performed on 3T MR. CBF was estimated using a fixed value of 43.5% (model 1) and individually measured Hct (model 2) to calculate the longitudinal relaxation time of blood in simplified Buxton equations. CBF estimates using individual Hct were lower than CBF estimates using a mean Hct in all ethnic and sex categories except white European men.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.