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Abstract #3775

Pitfall of synthetic MRI: Effect of gadolinium on the estimation of brain tissue volumes and myelin based on rapid simultaneous relaxometry

Tomoko Maekawa1,2, Akifumi Hagiwara1,2, Masaaki Hori1, Koji Kamagata1, Christina Andica1, Takuya Haruyama1,3, Kanako Sato1, Saori Koshino1,2, Ryusuke Irie1,2, Akihiko Wada1, and Shigeki Aoki1

1Radiology, Juntendo University, Tokyo, Japan, 2Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

We investigated the effect of gadolinium on the automatic tissue and myelin volumetry using synthetic MRI. 17 patients with metastases and 19 patients without metastasis were retrospectively analyzed before and after administration of gadolinium. After gadolinium administration, white matter volume (ml), non-white matter/gray matter/cerebrospinal fluid volume (ml), myelin volume (ml), and myelin volume/brain parenchymal volume (%) were significantly increased, whereas gray matter volume (ml), cerebrospinal fluid volume (ml), brain parenchymal volume (ml), and intracranial volume (ml) were significantly decreased regardless of metastasis. The gadolinium had significant effects on the automatic calculation of tissue and myelin volumes estimated by synthetic MRI.

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