We investigated the effect of gadolinium on the automatic tissue and myelin volumetry using synthetic MRI. 17 patients with metastases and 19 patients without metastasis were retrospectively analyzed before and after administration of gadolinium. After gadolinium administration, white matter volume (ml), non-white matter/gray matter/cerebrospinal fluid volume (ml), myelin volume (ml), and myelin volume/brain parenchymal volume (%) were significantly increased, whereas gray matter volume (ml), cerebrospinal fluid volume (ml), brain parenchymal volume (ml), and intracranial volume (ml) were significantly decreased regardless of metastasis. The gadolinium had significant effects on the automatic calculation of tissue and myelin volumes estimated by synthetic MRI.
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