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Abstract #3777

Increased Deposition of Iron in Deep Cerebral Gray Matter Structures in Hemodialysis Patients: A Longitudinal, Susceptibility-Weighted Image Mapping Study

Chao Chai1,2, Saifeng Liu3, Huiying Wang1, Jinping Li4, Tianyi Qian5, E. Mark Haacke6, Shuang Xia1, and Wen Shen1

1Radiology Department, Tianjin First Central Hospital, Tianjin, China, 2The first Central Hospital Affiliated to Nankai University, Tianjin, China, 3The MRI Institute for Biomedical Research, Waterloo, ON, Canada, 4Department of Hemodialysis, Tianjin First Central Hospital, Tianjin, China, 5MR Collaboration NE Asia, Siemens Healthcare, beijing, China, 6Department of Radiology, Wayne State University, Detroit, MI, United States

The aim of this study was to explore the changes in abnormal iron deposition in hemodialysis patients by longitudinal follow-up MR exam with susceptibility-weighted image mapping (SWIM). SWIM was reconstructed from the magnitude and phase data of SWI to quantify the susceptibility of deep gray matter nuclei in patients with a baseline examination and follow-up examination, and in healthy controls. The results suggest that iron deposition in the gray matter nuclei in patients increased over time, and this process may be a risk factor for neurocognitive dysfunction. The independent risk factors for abnormal iron deposition included the follow-up interval, creatinine, and abnormal calcium-phosphorus metabolism.

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