Abstract #3777

Increased Deposition of Iron in Deep Cerebral Gray Matter Structures in Hemodialysis Patients: A Longitudinal, Susceptibility-Weighted Image Mapping Study

Chao Chai^1,2, Saifeng Liu³, Huiying Wang¹, Jinping Li⁴, Tianyi Qian⁵, E. Mark Haacke⁶, Shuang Xia¹, and Wen Shen¹

¹Radiology Department, Tianjin First Central Hospital, Tianjin, China, ²The first Central Hospital Affiliated to Nankai University, Tianjin, China, ³The MRI Institute for Biomedical Research, Waterloo, ON, Canada, ⁴Department of Hemodialysis, Tianjin First Central Hospital, Tianjin, China, ⁵MR Collaboration NE Asia, Siemens Healthcare, beijing, China, ⁶Department of Radiology, Wayne State University, Detroit, MI, United States

The aim of this study was to explore the changes in abnormal iron deposition in hemodialysis patients by longitudinal follow-up MR exam with susceptibility-weighted image mapping (SWIM). SWIM was reconstructed from the magnitude and phase data of SWI to quantify the susceptibility of deep gray matter nuclei in patients with a baseline examination and follow-up examination, and in healthy controls. The results suggest that iron deposition in the gray matter nuclei in patients increased over time, and this process may be a risk factor for neurocognitive dysfunction. The independent risk factors for abnormal iron deposition included the follow-up interval, creatinine, and abnormal calcium-phosphorus metabolism.

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