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Abstract #3782

Associations between tissue sodium concentration, age and cross-sectional area in the healthy spinal cord

Bhavana Shantilal Solanky1, Ferran Prados2, Marios C Yiannakas1, Vanessa Bassan1, Baris Kanber2, Sebastien Ourselin2, Olga Ciccarelli1, and Claudia Angela Gandini Wheeler-Kingshott1,3,4

1Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Translational Imaging Group, Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, 3Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 4Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy

Tissue sodium concentration has recently come into the spotlight for a number of neurological conditions, given its potential role in neurodegeneration and due to the advances in MRI technology. This has led to many studies in the brain, but there is a shortage of studies characterising sodium in the spinal cord. Here we use 23Na-MRS to measure sodium in the healthy spinal cord and look at the association between tissue sodium concentrations with age and spinal cord cross sectional area.

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