Abstract #3812

Response Assessment in Carbon-Ion Radiotherapy of Recurrent High Grade Glioma through Characterization of Tumor Vascularization and Perfusion using DCE MRI

Charlotte Debus^1,2,3,4, Maximilian Knoll^1,2,3,4, Ralf Floca^3,5, Sebastian Adeberg^3,4, Jürgen Debus^1,2,3,4, and Amir Abdollahi^1,2,3,4

¹German Cancer Consortium (DKTK), Heidelberg, Germany, ²Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ⁴Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany, ⁵Division of Medical Image Computing, German Cancer Resarch Center, Heidelberg, Germany

Carbon-ion radiotherapy holds great potential for treatment of recurrent high-grade glioma, where re-irradiation is difficult due to prior dose burden. We investigated effects of carbon RT on tumor micro-vascularization and micro-circulation, by evaluating semi-quantitative parameters derived from DCE MRI before and after irradiation. Results show augmented perfusion parameters AUC, maximum enhancement and wash-out after therapy compared to pre-RT scans, and lower AUC, wash-in, wash-out and final uptake for responders to therapy compared to non-responders. Additionally, significantly lower values for AUC, wash-out, maximum enhancement and final uptake could be observed for progressed tumor volumes compared to irradiated tumor volumes.

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