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Abstract #3812

Response Assessment in Carbon-Ion Radiotherapy of Recurrent High Grade Glioma through Characterization of Tumor Vascularization and Perfusion using DCE MRI

Charlotte Debus1,2,3,4, Maximilian Knoll1,2,3,4, Ralf Floca3,5, Sebastian Adeberg3,4, J├╝rgen Debus1,2,3,4, and Amir Abdollahi1,2,3,4

1German Cancer Consortium (DKTK), Heidelberg, Germany, 2Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, 4Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany, 5Division of Medical Image Computing, German Cancer Resarch Center, Heidelberg, Germany

Carbon-ion radiotherapy holds great potential for treatment of recurrent high-grade glioma, where re-irradiation is difficult due to prior dose burden. We investigated effects of carbon RT on tumor micro-vascularization and micro-circulation, by evaluating semi-quantitative parameters derived from DCE MRI before and after irradiation. Results show augmented perfusion parameters AUC, maximum enhancement and wash-out after therapy compared to pre-RT scans, and lower AUC, wash-in, wash-out and final uptake for responders to therapy compared to non-responders. Additionally, significantly lower values for AUC, wash-out, maximum enhancement and final uptake could be observed for progressed tumor volumes compared to irradiated tumor volumes.

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