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Abstract #3842

Arbitrary Variable Density (AVD)-GRAPPA Enabled EPSI of Short-echo 3D H1-MRSI

Maryam Vareth1,2, Yan Li1, Misung Han1, Marram P. Olson1, Jason Crane1, Sarah J. Nelson1,3, and Janine M. Lupo1,3

1Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Berkeley Institude of Data Science, Univeristy of Califonia, Berkeley, Berkeley, CA, United States, 3UCSF/UCBerkeley Joint Graduate Group in Bioengineering, San Francisco, CA, United States

This work investigates the feasibility of using arbitrary sampling patterns and GRAPPA-EPSI reconstruction to shorten the acquisition time and increase the spatial resolution of short-echo 3D-MRSI for routine clinical purposes. Fully sampled data were retrospectively under-sampled to achieve effective acceleration rates of 2, 3 and 4 using a variety of sampling patterns. The modified GRAPPA algorithm: 1) took advantage of the FID time points, 2) handled arbitrary sampling patterns, and 3) used a fast, high-resolution external calibration acquisition to estimate sensitivity maps.

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