Abstract #3901

Feasibility of the in vivo measurement of acetate metabolism by 1H-[13C] MRS at 14.1T in the mouse hypothalamus

Blanca Lizarbe¹, Irene Guadilla², and Rolf Gruetter^1,3,4

¹Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Féderal de Lausanne, Lausanne, Switzerland, ²Instituto de Investigaciones Biomedicas "Alberto Sols" CSIC-UAM, Madrid, Spain, ³University of Lausanne, Lausanne, Switzerland, ⁴University of Geneva, Geneva, Switzerland

Astrocytic metabolism is impaired in many central nervous system diseases, like obesity or diabetes. Using ¹H-[¹³C] MRS together with [2-¹³C]acetate infusion in a 14.1T magnet, we have measured the incorporation of ¹³C labeling in the mouse hypothalamus in vivo, and calculated its metabolic fluxes using a two-compartment metabolic model that distinguishes between neurons and astrocytes. We think that these results open the possibility of investigating local variations of astrocytic metabolism in the mouse hypothalamus in vivo.

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