Abstract #3915

Low nodal plasma volume is associated with poor treatment response in head and neck cancer treated with induction chemotherapy.

Rafal Panek^1,2, Kee H. Wong^3,4, Liam Welsh^3,4, Alex Dunlop³, Dualta Mcquaid³, Angela M. Riddell³, Dow-Mu Koh^3,4, Martin O. Leach^3,4, Shreerang A. Bhide^3,4, Kevin J. Harrington^3,4, Christopher M. Nutting³, Kate L. Newbold³, and Maria Schmidt^3,4

¹Nottingham University Hospitals, Nottingham, United Kingdom, ²University of Nottingham, Nottingham, United Kingdom, ³The Royal Marsden NHS Foundation, London, United Kingdom, ⁴The Institute of Cancer Research, London, United Kingdom

Impaired tumour perfusion results in decreased efficacy of cancer treatment. In this work we investigated the optimal timing and predictive value of early chemotherapy induced changes, measured by dynamic contrast enhanced (DCE) and longitudinal intrinsic susceptibility (IS) MRI. We observed lower plasma volume in metastatic nodes responding poorly to the treatment. We found that for HNSCC patients treated with induction chemotherapy, combining DCE and IS-MRI methods improves early predictive value. This methodology could be used to aid patient stratification and subsequent radiotherapy treatment planning.

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