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Abstract #3922

Rectal cancer: multi-parametric MRI 3-dimensional assessment of intra-tumour heterogeneity and chemoradiotherapy response prediction

Trang Thanh Pham1,2,3,4,5, Gary Liney1,3,4, Karen Wong1,3,4, Christopher Henderson3,5,6, Robba Rai1,3, Petra L Graham7, Malcolm Hudson7,8, Nira Borok9, Minh Xuan Truong9, Mark Lee1,3, Joo-Shik Shin6, and Michael B. Barton 1,3,4

1Radiation Oncology, Liverpool Cancer Therapy Centre, Liverpool Hospital, Sydney, Australia, 2Sydney West Radiation Oncology Network, Westmead, Blacktown and Nepean Hospitals, Sydney, Australia, 3Faculty of Medicine, University of New South Wales, Sydney, Australia, 4Ingham Institute for Applied Medical Research, Sydney, Australia, 5School of Medicine, Western Sydney University, Sydney, Australia, 6Anatomical Pathology, Liverpool Hospital, Sydney, Australia, 7Department of Statistics, Macquarie University, Sydney, Australia, 8NHMRC Clinical Trials Centre, Sydney, Australia, 9Radiology, Liverpool Hospital, Sydney, Australia

This study investigated 3D quantitative histogram assessment of diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) MRI in the prediction of chemoradiotherapy (CRT) response in locally advanced rectal cancer. Histopathologic response assessment was centralised and defined according to AJCC tumour regression grade. A whole tumour histogram analysis and combined multiparametric scatterplots of ADC and Ktrans were used to assess tumour heterogeneity and prediction of CRT response. Post-CRT ADC 75th and 90th histogram quantiles were the most promising parameters for prediction of CRT response. However, DCE-MRI and multi-parametric scatterplots combining ADC and Ktrans did not add value in predicting response.

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