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Abstract #3925

Assessment of Tumor Microenvironment to Determine the Most Suitable Therapeutic Window in an Ovarian Cancer Model

Sarah Belderbos1, Kristof Govaerts1, Anca Croitor Sava1, Jens Wouters1, Bella B. Manshian1, Christophe M. Deroose1,2, Sabine Van Huffel3,4, Stefaan J. Soenen1, Willy Gsell1, and Uwe Himmelreich1

1Imaging and Pathology, KU Leuven, Leuven, Belgium, 2UZ Leuven, Leuven, Belgium, 3ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium, 4Imec, Leuven, Belgium

Multimodal imaging, i.e. combining (simultaneous) positron emission tomography (PET)-magnetic resonance imaging (MRI) and bioluminescence imaging (BLI) allows in-depth assessment of changes in tumor microenvironment over time. In this study, the development of human ovarian xenografts in mice was longitudinally monitored using BLI and PET-MRI to identify the most suitable time window to test nanomaterial-based therapies. Under these conditions, xenografts are viable, vascularized and metabolically active tumor masses with leaky blood vessels after four weeks, indicating a suitable time point for nanomaterial administration. This suggests that a combination of PET, MRI and BLI allows the identification of potential therapeutic windows.

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