DCE-MRI data from 54 breast cancer patients collected before and after one cycle of neoadjuvant chemotherapy were subjected to Shutter-Speed pharmacokinetic analysis. A new texture feature, multi-resolution fractal dimension (FD), was extracted from DCE-MRI parametric maps and compared with single-resolution FD for early prediction of therapy response. The multi-resolution approach appears to provide a richer description of the underlying tumor heterogeneity in perfusion/permeability than the single-resolution FD method, and has higher accuracy in early discrimination of pathologic complete response (pCR) from non-pCR.
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