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Abstract #3930

Diffusion-Weighted MRI Apparent Diffusion Coefficient (ADC) Histogram Changes In Primary Rectal Cancer Treated With Chemotherapy + Anti-Angiogenic Therapy Versus Neoadjuvant Chemoradiation

N. Jane Taylor1, Davide Prezzi2, J. James Stirling1, James A d'Arcy3, Rob Glynne-Jones4, and Vicky J Goh2

1Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, United Kingdom, 2Cancer Imaging, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 3CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, United Kingdom, 4Mount Vernon Hospital, Northwood, United Kingdom

Changes in the apparent diffusion co-efficient (ADC) histogram parameters in primary rectal cancers treated with neoadjuvant chemotherapy + anti-angiogenic therapy (NAC) differ substantially to those treated with chemoradiation (CRT), reflecting the differing mechanisms of action of these therapies. Higher diffusivity and lower variance post-CRT compared to NAC in responders likely reflects radiotherapy-related inflammation.

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