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Abstract #3936

Evaluation of Pharmacokinetic Models for Perfusion Imaging with Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Skeletal Muscle Using Low-Molecular-Weight Contrast Agents

Stefan Hindel1, Giorgos Papanastasiou2, Peter Wust3, Marc Maaß4, Anika Söhner1, and Lutz Lüdemann1

1Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Essen, Essen, Germany, 2Centre for Cardiovascular Science, Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Department of General and Visceral Surgery, Protestant Hospital Wesel, Wesel, Germany

Pharmacokinetic models for perfusion quantification with DCE-MRI using a low-molecular-weight contrast agent (LMCA) in skeletal muscle of pigs were validated. This in vivo study included compartmental and distributed parameter models which allow estimation of the functional and structural composition of heterogeneously perfused tissues. The different tracer kinetic models, which measure transport parameters in physically meaningful units in heterogeneous tissue, were compared to identify a method that allows reliable quantitative determination of physiological parameters. Double-contrast agent DCE-MRI using LMCA and intravascular CA in combination with the 2-compartment exchange model extended by a nonnutritive arteriolar compartment yields the most reliable results.

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