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Abstract #3944

Population variation in tumour microvascular characteristics

Ross A Little1, Hervé Barjat2, Jennifer I Hare3, Mary Jenner2, Yvonne Watson1, Susan Cheung1, Katherine Holliday1, Weijuan Zhang1, James PB O'Connor1, Simon T Barry3, Sanyogitta Puri4, Geoff JM Parker1, and John C Waterton1

1University of Manchester, Manchester, United Kingdom, 2formerly AstraZeneca, Alderley Park, United Kingdom, 3AstraZeneca, Cambridge, United Kingdom, 4AstraZeneca, Alderley Park, United Kingdom

It is unclear from the literature whether microvascular characteristics vary according to primary tumour type, although this is important for e.g. patient selection in drug development. DCE-MRI data were obtained covering 342 tumours and 13 tumour types. Median Ktrans for non-glioma tumours had geometric mean (95% CI) of 0.15 min-1 (0.05 min-1, 0.45 min-1). There was insufficient separation between posterior densities to predict tumour Ktrans given primary tumour type. This demonstrates that where microvascular characteristics are relevant for inclusion in a clinical trial or for beginning a specific treatment, it is not generally possible to select on tumour type alone.

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