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Abstract #3981

Effect of DRD4 receptor −616 C/G polymorphism on thalamic GABA levels in pediatric primary nocturnal enuresis patients

Yi You1, Zijun Li1, Xiaoqi Wang2, and Bing Yu1

1Shengjing Hospital of China Medical University, Shenyang, China, 2Philips Healthcare China, Beijing, China

The objective of this study is to explore the effect of DRD4 −616 C/G single nucleotide polymorphism (SNP) on thalamic GABA levels in with primary nocturnal enuresis (PNE). Results indicates the DRD4 −616 C allele is associated with increased thalamic GABA levels and higher arousal from sleep (AS) scores in PNE children. This research helps us understand the genetic susceptibility of the DRD4 −616 C allele to PNE.

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