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Abstract #4002

Mapping longitudinal changes in brain oxygenation in vascular cognitive impairment using 19F-MRI

Ahmed A Khalil1,2,3, Susanne Mueller1,4, Marco Foddis1, Janet Lips1, Ulrich Dirnagl1, Sebastian Temme5, Ulrich Floegel5, and Philipp Boehm-Sturm1,4

1Department of Experimental Neurology and Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, 2Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany, 3Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Cluster of Excellence NeuroCure and Charité Core Facility 7T Experimental MRIs, Charité - Universitätsmedizin Berlin, Berlin, Germany, 5Institute of Molecular Cardiology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany

We assessed tissue oxygenation with 19F-MRI using perfluorocarbon emulsions in a mouse model of vascular cognitive impairment. Brain T1 values were measured using a cryogenic 19F/1H coil at multiple timepoints before and after surgery to induce bilateral common carotid artery stenosis and converted to pO2. T1 values decreased with increasing concentration of inhaled oxygen, and we observed a decrease in tissue pO2 following surgery which gradually recovered over four weeks. 19F-MRI of perfluorocarbon emulsions can be used for long-term assessment of brain tissue pO2 in vivo and may be relevant for monitoring endogenous or induced regenerative processes.

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