Abstract #4005

Effects of Fraction of Inhaled Oxygen on Hyperpolarized 129Xe MR Signals Acquired from the Rat Brain In Vivo

Yonni Friedlander^1,2, Marcus Couch^1,2, Andrea Kassner^1,3, and Giles Santyr^1,2

¹Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Medical Imaging, University of Toronto, Toronto, ON, Canada

A theoretical model was developed to describe the dependence of the signal strength of ¹²⁹Xe dissolved in the rat brain on the fraction of inhaled oxygen (F_iO₂). To validate the model, ¹²⁹Xe MR signals were measured in the rat brain in vivo for four different values of F_iO₂ using a continuous ventilation scheme. The measured ¹²⁹Xe RBC signal showed a strong dependence on F_iO₂ in good agreement with the trends predicted by the theoretical model. These results underscore the need to optimize and control F_iO₂ when using ¹²⁹Xe signals to probe brain function.

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