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Abstract #4018

The effect of a 12-week aerobic exercise intervention on neurometabolites in young healthy adults using 7T 1H-MRS

Anouk Schrantee1,2,3, Jannie Wijnen4, Michelle M Solleveld1,3, Aart J Nederveen1, Serge Dumoulin2,5, Dennis WJ Klomp4, Liesbeth Reneman1, and Paul J Lucassen3

1Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Spinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands, 3Swammerdam Institute for Life Sciences, Center for Neurosciences, University of Amsterdam, Amsterdam, Netherlands, 4Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, Netherlands

Prolonged exercise has beneficial effects on cognition, which could be mediated by changes in neuronal metabolism. We present the first 7T MRS exercise study investigating neurometabolite concentrations before and after randomization to aerobic exercise or toning exercise in a large sample of healthy volunteers. We found that change in cardiovascular fitness was positively associated with changes in hippocampus glutamine, and negatively associated with change in glutamate in the anterior cingulate cortex; regardless of exercise group. This suggests that exercise-induced metabolic changes might not specific to the hippocampus, and that exercise likely has widespread effects on brain metabolism.

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