Generalized anxiety disorder (GAD) negatively affects emotional regulation and cognitive function. However, the causality between neurofunctional and metabolic brain alterations is not clearly revealed since the brain function and metabolic studies have been independently performed. A combined fMRI and 1H-MRS study would be necessary to investigate whether both of the brain functional abnormality and the metabolic changes are associated with the emotional dysregulation and cognitive deficit in GAD. Therefore, the purpose of this study was to assess the association between neurofunctional deficits and cellular metabolic changes under working memory (WM) tasks in patients with GAD.
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