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Abstract #4029

Betaine detection in human brain

Stefan Bluml1,2, Jessica L Wisnowski1,2, Marvin D Nelson1, and Tai-Wei Wu1

1USC/Children's Hospital Los Angeles, Los Angeles, CA, United States, 2Rudi Schulte Research Institute, Santa Barbara, CA, United States

Betaine, an essential osmolyte and source of methyl groups, is a metabolite known to be present in brain. However, due to its low concentrations and its overlap with the choline signal, betaine detection and quantitation is difficulty. In this study, we quantified betaine in high-quality spectra of pediatric patients and controls. The measured betaine concentrations of 0.1 - 0.2 mM are consistent with what has been measured in rat brain extracts by high-field NMR.

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