Abstract #4043

Synergistic effect of MR-HIFU hyperthermia mediated drug delivery followed by ablation

Edwin Heijman¹, Nicole Hijnen², Esther Kneepkens², Mariska de Smet², Sander Langereis³, and Holger Grüll⁴

¹Oncology Solutions, Philips Research, Cologne, Germany, ²Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, ³Oncology Solutions, Philips Research, Eindhoven, Netherlands, ⁴Department of Radiology, Experimental Imaging and Image-guided Therapy, University Hospital of Cologne, Cologne, Netherlands

Four Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) thermal therapy strategies (no HIFU, hyperthermia, ablation and hyperthermia followed by ablation) in combination with temperature sensitive liposomes (TSLs), co-encapsulating doxorubicin (dox) and ProHance®, were investigated in rhabdomyosarcoma rat tumor model. All HIFU heating strategies combined with TSLs resulted in cellular uptake of dox deep into the interstitial space and significant increase of intratumoral drug concentrations. The combination of hyperthermia-triggered TSLs followed by ablation showed the best therapeutic outcome compared to other strategies due to direct induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.

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