Abstract #4054

Longitudinal Observation of Focused Ultrasound Induced Blood-Brain Barrier Opening of Cat Brain from 7-T Contrast-Enhanced MRI

Xianfeng Feng#¹, Tingting He#¹, Xiao Yu¹, Chih-Hung Tsai², Wen-Yen Chai³, Chao-Ting Wang^1,2, Wei Xiong¹, Bin Xu¹, Yifeng Fan¹, Hao-Li Liu*^1,2, and Hsin-Yi Lai*¹

¹Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou City, China, ²School of Medicine, Department of Electrical Engineering, Chang Gung University, Taoyuan County, Taipei City, Taiwan, ³Department of Diagnostic Radiology and Intervention, Chang Gung Memorial Hospital, Taoyuan County, Taiwan

Blood-brain barrier (BBB) has long been impeding the application of many therapeutic agents in treating diseases in central nervous system. Results showed that microbubble-mediated focused ultrasound can open BBB in cats noninvasively and locally. The size and duration of BBB opening can be accurately monitored by 7T MRI longitudinally. The combination of two techniques has the potential to be further applied for further clinical practice in the future.

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