Blood-brain barrier (BBB) has long been impeding the application of many therapeutic agents in treating diseases in central nervous system. Results showed that microbubble-mediated focused ultrasound can open BBB in cats noninvasively and locally. The size and duration of BBB opening can be accurately monitored by 7T MRI longitudinally. The combination of two techniques has the potential to be further applied for further clinical practice in the future.
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