A thermal contrast agent with high sensitivity, thulium 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA-), was investigated for use in measuring the three-dimensional heating profile surrounding implantable devices with a goal of simplifying the safety assessment process. The technique was first demonstrated by imaging a vertical temperature gradient and was subsequently used to measure the heating profile surrounding a copper wire. We found gross agreement of this technique with concurrent fiber-optic temperature probe measurements, with the TmDOTMA- measurement complicated by a number of technical challenges and imaging artifacts.
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