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Abstract #4065

Image-Based MR Safety Evaluation of Heating in Implanted Devices

Samuel Rob Guyer1, Ken Sakaie2, Se-Hong Oh2,3, and Stephen Jones2

1School of Medicine, Case Western Reserve University, Cleveland, OH, United States, 2Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States, 3Department of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Republic of Korea

A thermal contrast agent with high sensitivity, thulium 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA-), was investigated for use in measuring the three-dimensional heating profile surrounding implantable devices with a goal of simplifying the safety assessment process. The technique was first demonstrated by imaging a vertical temperature gradient and was subsequently used to measure the heating profile surrounding a copper wire. We found gross agreement of this technique with concurrent fiber-optic temperature probe measurements, with the TmDOTMA- measurement complicated by a number of technical challenges and imaging artifacts.

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