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Abstract #4127

fMRI at 7 Tesla with 0.5mm Isotropic Resolution and Full Field of View

Patrick Liebig1,2,3, Robin Martin Heidemann2, Bernhard Hensel1, Yuehui Tao4, Wei Liu5, and David Porter3

1Center of medical physics and engineering, University of Erlangen-Nuremberg, Erlangen, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3University of Glasgow, Glasgow, United Kingdom, 4Siemens Healthcare United Kingdom, Glasgow, United Kingdom, 5Siemens Shenzen Magnetic Resonance Ltd., Shenzen, China

fMRI protocols at ultra-high field typically use pixel sizes below 1mm. With single-shot EPI, this results in a prolonged readout train relative to the T2* decay time, resulting in image blurring and a limit to the true resolution that can be achieved. This effect can be mitigated by using multi-shot EPI to reduce the echo-train length, but this is associated with a reduction in temporal SNR. Previous work demonstrated a less severe reduction in temporal stability with readout-segmented EPI than with interleaved EPI. This study investigates the application of readout-segmented EPI to ultra-high resolution fMRI of the motor cortex.

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