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Abstract #4133

Enhancing Spatial-Temporal Resolution in Simultaneous Multi-Slab Echo Volumar Imaging

Kishore Vakamudi1, Steen Moeller2, Sudhir Ramanna2, Akio Yoshimoto3, Essa Yacoub2, Ricardo Otazo3, Alam Abbas Syed4, and Stefan Posse1

1Neurology, Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States, 2Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States, 3Center for Advanced Imaging, Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, 4Neurology, University of New Mexico, Albuquerque, NM, United States

We develop multi-band echo-volumar-imaging (MB-EVI) by combining multi-slab encoding with EVI to investigate BOLD sensitivity, resting-state connectivity in different frequency bands, and spatial-temporal resolution limits. We also study the effect of compressed sensing (CS) reconstruction on fMRI sensitivity. Mapping of major resting-state networks with 3mm3 voxel size was feasible in multiple frequency bands. High spatial resolution (2mm3) improved delineation of neuroanatomy and enabled sensitive mapping task-based activation. CS with 2.4-fold undersampling showed negligible loss in image quality and moderate region-specific losses in BOLD sensitivity. MB-EVI provides flexibility for maximizing spatial-temporal resolution, volume-coverage and BOLD-sensitivity for mapping task-activation and functional connectivity.

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