Abstract #4133

Enhancing Spatial-Temporal Resolution in Simultaneous Multi-Slab Echo Volumar Imaging

Kishore Vakamudi¹, Steen Moeller², Sudhir Ramanna², Akio Yoshimoto³, Essa Yacoub², Ricardo Otazo³, Alam Abbas Syed⁴, and Stefan Posse¹

¹Neurology, Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States, ²Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States, ³Center for Advanced Imaging, Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, ⁴Neurology, University of New Mexico, Albuquerque, NM, United States

We develop multi-band echo-volumar-imaging (MB-EVI) by combining multi-slab encoding with EVI to investigate BOLD sensitivity, resting-state connectivity in different frequency bands, and spatial-temporal resolution limits. We also study the effect of compressed sensing (CS) reconstruction on fMRI sensitivity. Mapping of major resting-state networks with 3mm³ voxel size was feasible in multiple frequency bands. High spatial resolution (2mm³) improved delineation of neuroanatomy and enabled sensitive mapping task-based activation. CS with 2.4-fold undersampling showed negligible loss in image quality and moderate region-specific losses in BOLD sensitivity. MB-EVI provides flexibility for maximizing spatial-temporal resolution, volume-coverage and BOLD-sensitivity for mapping task-activation and functional connectivity.

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