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Abstract #4157

Transcatheter intra-arterial perfusion (TRIP)-MRI for the evaluation of immediate Irreversible Electroporation effects in the VX2 rabbit liver tumor model.

Matteo Figini1, Kang Zhou1,2, Liang Pan1,3, Junjie Shangguan1, Chong Sun1,4, Bin Wang1,5, Na Shang1, Quanhong Ma1, Daniele Procissi1, Andrew Christian Larson1, and Zhuoli Zhang1

1Radiology, Northwestern University, Chicago, IL, United States, 2Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, 3Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, 4Orthopedics, Qilu Hospital, Shandong University, Jinan, China, 5General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

Six rabbits with liver tumors underwent anatomical and perfusion MRI immediately after irreversible electroporation (IRE) treatment of the tumors, using a catheter inserted in the left hepatic artery to deliver the contrast agent (TRIP-MRI). All the treated regions showed low perfusion as measured by the Area under the tissue response Curve. In some cases, a rim or a few spots with higher AUC were present, and were presumably associated with the penumbra of reversible electroporation that is known to be present in IRE-treated tissues. TRIP-MRI could be a valuable non-invasive tool to assess IRE effect and to immediately plan retreatment.

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