Abstract #4171

Assessment of Immediate Response to Irreversible Electroporation for Targeted Ablation of Liver Tissues Using Dynamic Contrast Enhancement in a Rabbit Model

Junjie Shangguan^1,2, Matteo Figini¹, Chong Sun^1,3, Liang Pan^1,4, Bin Wang^1,5, Quanhong Ma¹, Kang Zhou^1,6, Na Shang¹, and Zhuoli Zhang¹

¹Department of Radiology, Northwestern University, Chicago, IL, United States, ²Driskill Graduate Program, Northwestern University, Chicago, IL, United States, ³Orthopedics, Qilu Hospital, Shandong University, Jinan, China, ⁴Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, ⁵General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁶Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Irreversible electroporation (IRE) may be visualized by MRI immediately post-procedure to monitor and assess tissue response peri-operatively. Dynamic contrast-enhanced MRI (DCE-MRI) allows measurement of tissue perfusion. We will demonstrate that DCE-MRI allows early visualization of IRE ablated tissue margins for prediction of the ablated region and quantification of tissue response. 6 rabbits underwent IRE ablation of the liver and pre-IRE and post-IRE DCE-MRI. A decrease in post-IRE apparent diffusion coefficients in the ablated region compared with baseline indicates tissue damage. Post-IRE AUC is decreased compared with baseline, suggesting decreased but still present blood perfusion in the ablated region post-IRE.

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