Abstract #4235

AC magnetic sensing using the SIRS effect combined with bSSFP at ultra-low field

Bragi Sveinsson^1,2,3, Neha Koonjoo^1,2,3, Bo Zhu^1,2,3, Thomas Witzel^1,2, and Matthew Rosen^1,2,3

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Physics, Harvard University, Cambridge, MA, United States

Direct detection of neuronal currents has long been a goal within MRI, with the aim of improving upon the spatial and temporal resolution of BOLD fMRI. So far, good results have been shown in phantoms but detection in vivo has proven difficult. A promising current detection technique is Stimulus-Induced Rotary Saturation (SIRS), but the BOLD signal can contaminate SIRS measurements, possibly explaining inconclusive in vivo results so far. A new sequence was developed and tested in an ultra-low-field (ULF) regime (6.5 mT) where paramagnetic effects such as BOLD are reduced and is more suited for SIRS measurements in vivo.

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