Abstract #4247

Simultaneous Observation of Two Paramagnetic MRI Contrast Agents via Dynamic T1 and T2 Mapping with Magnetic Resonance Fingerprinting: Initial In Vivo Results

Christian E Anderson^1,2, Yuning Gu², Mette Johansen^3,4, He Hu², Yun Jiang¹, Michael Kavran¹, Bernadette Erokwu¹, Susann Brady-Kalnay^3,4, Nicole Steinmetz^1,2, Xin Yu^2,5, Mark Griswold^1,2, and Chris Flask^1,2,6

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Neurosciences, Case Western Reserve University, Cleveland, OH, United States, ⁵Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, ⁶Pediatrics, Case Western Reserve University, Cleveland, OH, United States

In this work simultaneous T1 and T2 mapping via MR Fingerprinting was used to observe the distribution of dysprosium and gadolinium MRI contrast agents in a mouse tumor model. Changes from baseline in T1 and T2 were observed using each agent alone and an increased effect was seen when agents were used in combination. Additionally, a decrease in the dysprosium dose lead to a reduction in the level of T1 and T2 enhancement observed. These results indicate that MRF might be able to be used to track multiple MRI contrast agents in vivo.

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