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Abstract #4256

Magnetic Resonance Fingerprinting (MRF) Can Reveal Microstructural Variations in the Brain Gray Matter

Shahrzad Moeiniyan Bagheri1, Viktor Vegh1, and David C Reutens1

1Centre for Advanced Imaging, The University of Queensland, ST LUCIA, Australia

The importance of creating accurate anatomical maps of the human brain has motivated the development of in vivo, observer-independent and reproducible mapping methods that account for inter-individual variation. However, a) whole brain coverage and b) a multi-modal approach that accounts for the combined effects of all microscale tissue properties has yet to be developed. To bridge this gap, we propose a statistical feature-based residual analysis framework that makes use of unique tissue-specific MRF signals after taking account of T1 and T2* effects. In four cortical areas of six participants, this approach showed consistent similarity measurements between regions, indicating that MRF signals contain information about micro-level tissue properties.

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