Abstract #4262

Unbalanced Steady-State Free Precession MR Fingerprinting with Simultaneous Fat Signal Fraction, T1, T2 and B0 Estimation

Jason Ostenson^1,2, Bruce M. Damon^1,2,3,4,5, and E. Brian Welch^1,3,5

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁴Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States, ⁵Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Unbalanced steady-state free precession MR fingerprinting (uSSFP-MRF) may be used to quantify fat signal as well as water T1 and T2, but is subject to off-resonance (B0) and blurring. We propose a variable echo time uSSFP and post-processing method that estimates fat signal fraction, water T1 and T2, and B0 within a single sequence. The method is tested in phantoms and in vivo. Preliminary results indicate the proposed method provides sharp fat fraction maps that account for chemical-shift and B0 effects that normally lead to blurring, as well as generate water-only T1 and T2 maps.

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