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Abstract #4276

SNR Improvement of In Vivo 31P MRSI in Human Brain using Head-Shape Ultrahigh Dielectric Constant Material at 7T

Byeong-Yeul Lee1, Xiao-Hong Zhu1, Sebastian Rupprecht2, Maryam Sarkarat3, Michael T. Lanagan3, Qing X. Yang2, and Wei Chen1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 2Center for Nuclear Magnetic Resonance Research, Department of Radiology, The Penn State College of Medicine, Hershey, PA, United States, 3Department of Engineering and Science and Mechanics, The Penn State College of Engineering, University Park, PA, United States

Increased RF power (thus, higher SAR) and inadequate detection sensitivity (or SNR) even at high/ultrahigh field are the major challenges for X-nuclei MRS imaging (MRSI) for human applications. In this work, we demonstrate that using the ultrahigh dielectric constant material (uHDM) conformed to the human head incorporated into the RF head volume coil, improved detection sensitivity and reduced demand of RF transmit power were achieved across an entire object for testing phantom and human brain 31P MRSI at 7T. Therefore, incorporating optimized geometry of uHDM with RF coil can significantly boost SNR and reduce SAR in X-nuclei MRS applications, ultimately, improve spatiotemporal resolution.

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