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Abstract #4329

Time makes the difference: Comparison of ADC values obtained with OGSE and PGSE sequences for differentiation of human breast tumors

Mami Iima1,2, Masako Kataoka1, Kanae Kawai Miyake1, Maya Honda1, Rena Sakaguchi1, Ayami Ohno Kishimoto1, Mizue Suzuki1, Katsutoshi Murata3, Thorsten Feiweier4, Masakazu Toi5, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan, 3Siemens Healthcare K.K., Tokyo, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

The diffusion time dependence of ADC measurements has been investigated using OGSE and PGSE sequences in human breast tumors. Relative changes in ADC values corresponding to two diffusion times, in addition to ADC values for each diffusion time were calculated in malignant and benign breast lesions as well as in normal breast tissues. Significant differences of ADC changes, in addition to ADC values for each diffusion time, have been found among malignant and benign lesions and normal breast tissue. No ADC changes have been identified in a dedicated breast phantom. ADC maps corresponding to different diffusion times indicate that ADC changes might provide insight in revealing new tissue features like, for instance, intracellular structure of breast tumors.

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