Abstract #4343

Examination of Lung Function among Older Smokers with and without COPD by Apparent Diffusion Coefficient (ADC) of 3He MRI

Yanping Sun¹, Jia Guo², Pallavi P Balte¹, Stephen M Dashnaw³, Martin R Prince³, Elizabeth C Oelsner¹, Christian M Lo Cascio¹, Mitchell S Albert⁴, Jim Wild⁵, Emlyn W Hughes⁶, and R. Graham Barr¹

¹Department of Medicine, Columbia University Medical School, New York, NY, United States, ²Department of Biomedical Engineer, Columbia University, New York, NY, United States, ³Department of Radiology, Columbia University Medical School, New York, NY, United States, ⁴Department of Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁵Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ⁶Department of Physics, Columbia University, New York, NY, United States

Chronic obstructive pulmonary disease (COPD) is defined as persistent airflow limitation by spirometry. However, some smokers with normal spriometry have significant respiratory symptoms. We used 3He apparent diffusion coefficient (ADC) to examine the lungs in older smokers with and without COPD (n=50). This study showed high ADC in both smokers with and without COPD. The difference in ADC between COPD and non-COPD was significant. ADC was correlated positively with percent emphysema and %FVC, and negatively with FEV1 to FVC ratio and, non-significantly with FEV1. 3He ADC may provide different information of lung microarchitecture from spirometry in smoking related pulmonary diseases.

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