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Abstract #4343

Examination of Lung Function among Older Smokers with and without COPD by Apparent Diffusion Coefficient (ADC) of 3He MRI

Yanping Sun1, Jia Guo2, Pallavi P Balte1, Stephen M Dashnaw3, Martin R Prince3, Elizabeth C Oelsner1, Christian M Lo Cascio1, Mitchell S Albert4, Jim Wild5, Emlyn W Hughes6, and R. Graham Barr1

1Department of Medicine, Columbia University Medical School, New York, NY, United States, 2Department of Biomedical Engineer, Columbia University, New York, NY, United States, 3Department of Radiology, Columbia University Medical School, New York, NY, United States, 4Department of Chemistry, Lakehead University, Thunder Bay, ON, Canada, 5Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 6Department of Physics, Columbia University, New York, NY, United States

Chronic obstructive pulmonary disease (COPD) is defined as persistent airflow limitation by spirometry. However, some smokers with normal spriometry have significant respiratory symptoms. We used 3He apparent diffusion coefficient (ADC) to examine the lungs in older smokers with and without COPD (n=50). This study showed high ADC in both smokers with and without COPD. The difference in ADC between COPD and non-COPD was significant. ADC was correlated positively with percent emphysema and %FVC, and negatively with FEV1 to FVC ratio and, non-significantly with FEV1. 3He ADC may provide different information of lung microarchitecture from spirometry in smoking related pulmonary diseases.

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