Abstract #4347

Quantification of Pulmonary Perfusion in Idiopathic Pulmonary Fibrosis: Preliminary Results

Luis A Torres¹, Wei Zha¹, Mu He², Bastiaan Driehuys³, and Sean B Fain¹

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Electrical and Computer Engineering, Duke University, Durham, NC, United States, ³Radiology, Duke University, Durham, NC, United States

IPF is a pulmonary disease with no validated biomarkers in current clinical use. Here, we compared pulmonary perfusion in an IPF subject versus healthy subject using Dynamic Contrast-Enhanced MRI (DCE-MRI). A decrease in PBF, PBV and an increase in MTT was seen in IPF compared to the healthy control. High spatial correlation of perfusion defects and fibrosis is seen when compared to the morphological images, suggesting DCE-MRI may prove to be a useful technique for evaluating IPF.

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