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Abstract #4362

Discovery and Verification of Lung Cancer Serum Biomarkers using Paired Tissue and Serum

Leo L. Cheng1, Isabella Dittmann1,2, Li Su3, Johannes Kurth1,2, Andreas Schuler1,2, Yannick Berker1, Lindsey A. Vandergrift1, Sarah S. Dinges1,2, Piet Habbel2, Eugene J. Mark1, and David C. Christiani3

1Pathology, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, Charite Medical University, Berlin, Germany, 3Environmental and Occupational Medicine, Harvard T. H. Chan School of Public Health, Boston, MA, United States

A widespread, minimally-invasive method for early detection of lung cancer is urgently needed in the lung cancer clinic. Using high resolution magic angle spinning magnetic resonance spectroscopy, we measured paired tissue and serum samples from the same patients. We correlated serum and tissue results to discover and verify serum markers for lung cancer types and stages and predicted overall survival for early Stage I lung cancer. Measured from serum, prolonged survival is associated with relative overexpression of glutamine, valine, glycine, and relative suppression of glucose and lipids.

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