Abstract #4362

Discovery and Verification of Lung Cancer Serum Biomarkers using Paired Tissue and Serum

Leo L. Cheng¹, Isabella Dittmann^1,2, Li Su³, Johannes Kurth^1,2, Andreas Schuler^1,2, Yannick Berker¹, Lindsey A. Vandergrift¹, Sarah S. Dinges^1,2, Piet Habbel², Eugene J. Mark¹, and David C. Christiani³

¹Pathology, Massachusetts General Hospital, Charlestown, MA, United States, ²Radiology, Charite Medical University, Berlin, Germany, ³Environmental and Occupational Medicine, Harvard T. H. Chan School of Public Health, Boston, MA, United States

A widespread, minimally-invasive method for early detection of lung cancer is urgently needed in the lung cancer clinic. Using high resolution magic angle spinning magnetic resonance spectroscopy, we measured paired tissue and serum samples from the same patients. We correlated serum and tissue results to discover and verify serum markers for lung cancer types and stages and predicted overall survival for early Stage I lung cancer. Measured from serum, prolonged survival is associated with relative overexpression of glutamine, valine, glycine, and relative suppression of glucose and lipids.

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