UTE with 3D variable-TE stack-of-spirals sampling has been developed recently and allows shorter scan times by using undersampling in combination with an iterative, self-consistent parallel imaging reconstruction (SPIRiT). The goal of this study was to investigate the feasibility of this new technique in patients for detecting pulmonary nodules. The sequence was optimized for both free-breathing and breath-holding. Compared with CT images, the detection rate for pulmonary nodules in the UTE images was 92% for free-breathing and 75% for breath-holding. Our results suggest that the proposed UTE sequence has the capacity to detect pulmonary nodules under both free-breathing and breath-holding conditions.