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Abstract #4372

Differentiating prostate cancer from benign prostatic hyperplasia using multiparametric MRI

Aritrick Chatterjee1, Alexander J Gallan2, Dianning He1,3, Xiaobing Fan1, Devkumar Mustafi1, Ambereen Yousuf1, Tatjana Antic2, Gregory S Karczmar1, and Aytekin Oto1

1Department of Radiology, University of Chicago, Chicago, IL, United States, 2Department of Pathology, University of Chicago, Chicago, IL, United States, 3Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China

This study investigates multiparametric MRI (mpMRI) appearance of different types of BPH and whether quantitative mpMRI is effective in differentiating between PCa and BPH in 60 patients. mpMRI and specifically quantitative ADC values can be used for differentiating PCa and BPH, improving PCa diagnosis in the transition zone. However, DCE-MRI metrics are not effective in distinguishing PCa and BPH. In contrast to previous understanding, glandular BPH has short T2 values (hypointense on T2-weighted images), demonstrates restricted diffusion, and may have similar quantitative mpMRI measurements to stromal BPH. Additionally, glandular and cystic BPH appear differently on mpMRI and are histologically different.

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